[μ-1,2-Bis(diphenyl­phosphan­yl)-1,2-diethyl­hydrazine-κ2 P:P′]bis­[chlorido­gold(I)] tetra­hydro­furan disolvate

The title compound, [Au2Cl2(C28H30N2P2)]·2C4H8O, was synthesized from a bidentate phosphine ligand complexed to two linear gold(I) chloride moieties. The Au(I) atom is in an almost linear coordination with a P—Au—Cl angle of 179.22 (4)°. The complex molecules reside on a twofold rotation axis

[μ-1,2-Bis(diphenyl­phosphan­yl)-1,2-dimethyl­hydrazine-κ2 P:P′]bis­[chlorido­gold(I)]

The title compound, [Au2Cl2(C26H26N2P2)], is formed from a bidentate phosphine ligand complexed to two linearly coordinated gold(I) atoms. The gold(I) atoms are 3.4873 (7) Å apart. The mol­ecule exhibits a crystallographic twofold rotation axis

Chlorido{N-[2-(diphenylphosphanyl)- benzyl]-1-(pyridin-2-yl)methanamine-kP} gold(I)

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1,2-Bis(diphenyl­phosphino)-1,2-diethyl­hydrazine

The title compound, C28H30N2P2, adopts a well documented and studied gauche conformation around the hydrazine bond. Bond lengths and angles are in the typical ranges expected for P—N and P—C bonds. A normal hydrazine N—N bond length of 1.426 (3) Å is observed

Poly[[μ2-1,2-bis­(diphenyl­phosphan­yl)-1,2-diethylhydrazine]-μ4-nitrato-μ2-nitrato-silver(I)]

The title compound, [Ag2(NO3)2(C28H30N2P2)]n, crystallizes in polymeric α-helices. Three O atoms from three different nitrate ions in equatorial positions and two Ag atoms at axial positions set up a trigonal bipyramid. These units are linked by the phosphine ligands into endless helical chains that run along the c axis. The crystal used for the data collection was a racemic twin

Conditions under which glutathione disrupts the biofilms and improves antibiotic efficacy of both ESKAPE and NON-ESKAPE species

Bacterial antibiotic resistance has increased in recent decades, raising concerns in hospital and community settings. Novel, innovative strategies are needed to eradicate bacteria, particularly within biofilms, and diminish the likelihood of recurrence. In this study, we investigated whether glutathione (GSH) can act as a biofilm disruptor, and enhance antibiotic effectiveness against various bacterial pathogens. Biological levels (10 mM) of GSH did not have a significant effect in inhibiting growth or disrupting the biofilm in four out of six species tested. However, exposure to 30 mM GSH showed >50% decrease in growth for all bacterial species, with almost 100% inhibition of Streptococcus pyogenes and an average of 94–52% inhibition for Escherichia coli, Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive S. aureus (MSSA) and multi-drug resistant Acinetobacter baumannii (MRAB) isolates, respectively. Klebsiella pneumoniae and Enterobacter sp. isolates were however, highly resistant to 30 mM GSH. With respect to biofilm viability, all species exhibited a >50% decrease in viability with 30 mM GSH, with confocal imaging showing considerable change in the biofilm architecture of MRAB isolates. The mechanism of GSH-mediated biofilm disruption is possibly due to a concentration-dependent increase in GSH acidity that triggers cleaving of the matrix components. Enzymatic treatment of MRAB revealed that eDNA and polysaccharides are essential for biofilm stability and eDNA removal enhanced amikacin efficiency. Combination of GSH, amikacin and DNase-I showed the greatest reduction in MRAB biofilm viability. Additionally, GSH alone and in combination with amikacin fostered human fibroblast cell (HFF-1) growth and confluence while inhibiting MRAB adhesion and colonization

Chlorido{N-[2-(diphenyl­phosphan­yl)benz­yl]-1-(pyridin-2-yl)methanamine-κP}gold(I)

In the title compound, [AuCl(C25H23N2P)], the AuI atom is in a typical almost linear coordination environment defined by phosphane P and Cl atoms [bond angle = 175.48 (4)°]. Helical supra­molecular chains along the b axis and mediated by N—H⋯Cl hydrogen bonds feature in the crystal packing

1,2,4,5-Tetramethyl-3,6-diphenyl-1,2,4,5-tetraaza-3,6-diphosphinane

The title compound, C16H22N4P2, crystallizes about a centre of symmetry, leading to a chair conformation of the heterocyclic ring as is commonly found for this type of compound